Generic Coreg

1. Denomination

Coreg

2. Active Substance

Carvedilol

3. Indications for Use.

Arterial hypertension (within a combined therapy and within a mono one)
Chronic heart failure (within a combined therapy) 
Ischemic heart disease: stable angina. In patients who suffer from ischemic heart disease Carvedilol takes anti-ischemic and anti-anginal effect, in patients who suffer from arterial hypertension the drug reduces arterial tension. Carvedilol also reduces preload (pulmonary artery wedge pressure and pulmonary capillary pressure) and afterload (general peripheral vascular resistance). Carvedilol is efficient and well tolerated by patients who suffer from chronic heart failure of any severity level; the drug reduces mortality of such patients.

4. Posology and Administration

The drug should be taken orally, rinsing it with fair quantity of liquid. When there is arterial hypertension it is to be taken 12.5 mg once daily in the first 2 days, then it should be taken 25 mg once daily with a possible gradual increase of the dose with an interval of not less than 2 weeks. When there is stenocardia it is to be taken 12.5 mg once daily in the first 2 days, then it should be taken 25 mg twice daily (at most up to 100 mg, divided into 2 intakes). When there is chronic heart failure (under pressure of matched combinative therapy) the treatment is to be started from 3.125 mg 2 times a day during 2 weeks, then (when the tolerance is good) the dose is increased up to 6.25 mg 2 times a day, then the dose should be increased up to 12.5-25 mg 2 times a day (when the body mass is less than 85 kg the maximal dose is 25 mg 2 times a day, when the body mass is more than 85 kg the dose should be 50 mg 2 times a day). If the treatment interrupts in more than 2 weeks, its resumption will be started from a dose of 3.125 mg 2 times a day, then the dose is to be increased.

5. Counterindications

Hypersensitivity, AV block of II-III-d degree, liver failure, evidenced bradycardia, SSS, cardiogenic shock, bronchial asthma, low arterial tension, lactation period, age under 18 (safety and efficiency have not been determined).

6. Should Be Taken with Precautions, if…

With caution the drug is used in ischemic heart disease patients and in patients who use contact lenses, as Carvedilol therapy results in decrease of delacrimation (special attention is needed). Withdrawal should be carried out little by little (in order to avoid progression of “withdrawal” syndrome), during several days (especially in ischemic heart disease patients). At the time of treatment alcohol consumption is not recommended.

7. Interface with Other Medications

Combined administration of medications without a doctor’s order is counterindicated!

8. Overdosing

Evidenced drop of arterial tension, bradycardia (less than 50 beats/minute), respiratory impairment (including bronchospasm), chronic heart failure, cardiogenic shock, heart arrest.

9. Side Effects

In the beginning of the treatment (first dose effect) and in increase of the dose - episodes of excessive drop of AT are possible. Usually such events pass in themselves, and the patient’s condition is stabilized without a special correction. When Carvedilol is continued to be used - there are possible events of weakness, fatigability, headache, bradycardia, hypersthenia and rise of intestinal motility; less frequently there are observed disorder of peripheral blood flow, attacks of stenocardia, AV block, episodes of intermittent lameness, likewise allergic exanthema, itching, hives, lichen-planus-like reactions, emergence of psoriasic patches or aggravation of the earlier existing psoriasic process. In specific cases there are reported sleep disorders, psychic depression, paresthesias, enhancement of manifestation of heart failure, stuffiness in nose, likewise disorders of blood composition.

10. Pregnancy and Lactation

There have not been carried out any controlled studies of the use of Carvedilol in pregnant women, therefore the drug administration is possible only in the cases when favor for the mother exceeds potential risk for the fetus. Breastfeeding during Carvedilol therapy is not recommended.

11. Driving

In the beginning of the treatment, likewise in the increase of a dose of Carvedilol in the process of treatment it is well to refrain from vehicle driving and from other activities which demand high concentration of attention and swift psychomotor reactions.

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Q. Can you tell me if I should be taking Generic Coreg ( Carvedilol 6.25/12.5/25mg ) ? Or, will it work for me?
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Q. What about importing of Generic Coreg ( Carvedilol 6.25/12.5/25mg ) to my country ?
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